Answer
Rituximab binds CD20 on pre-B and mature B cells through its Fab domain, while its Fc domain can recruit immune effectors to destroy B cells through complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity; binding to CD20 can also induce apoptosis.
Sources for this answer
- MabThera 100mg and 500mg Concentrate for Solution for InfusionRoche Products Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 57Document updated
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