rilpivirine · Medicine question

How does rilpivirine act against HIV-1?

iatroX medicinesPublished 8 November 2026

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Rilpivirine is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor (NNRTI) that acts against HIV-1 by non-competitively inhibiting HIV-1 reverse transcriptase.

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Rekambys 900 mg prolonged-release suspension for injectionJanssen-Cilag Ltd (a Johnson & Johnson Company) · emc · SmPC §5.1 Pharmacodynamic properties · Version 10Document updated 26 November 2025

Sources checked 8 November 2026

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Can oral rilpivirine be taken with proton pump inhibitors?Can Rekambys (rilpivirine) be used with St John's wort?How long can rilpivirine remain in the circulation after Rekambys injections are discontinued?How much sodium does each Rekambys (rilpivirine) injection contain?How soon after a Rekambys (rilpivirine) injection have serious post-injection reactions been reported?Which enzyme primarily metabolises rilpivirine?

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