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Medicines agomelatineQuestion & answer

agomelatine · Medicine question

How does rifampicin affect the bioavailability of agomelatine?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Rifampicin may decrease agomelatine bioavailability by inducing all three cytochromes involved in its metabolism.

Sources for this answer

ValdoxanServier Laboratories Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 20Document updated 29 November 2021

Sources checked 8 November 2026

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agomelatine

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