roflumilast · Medicine question

How does rifampicin affect the activity of roflumilast?

iatroX medicinesPublished 8 November 2026

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Rifampicin reduces roflumilast’s total PDE4 inhibitory activity by about 60%, potentially reducing therapeutic efficacy, so roflumilast treatment is not recommended in patients receiving rifampicin, a strong cytochrome P450 enzyme inducer.

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DAXAS 500 micrograms film-coated tabletsAstraZeneca UK Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 16Document updated 8 April 2024

Sources checked 8 November 2026

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