sunitinib · Medicine question

How does rifampicin affect sunitinib concentrations?

iatroX medicinesPublished 8 November 2026

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Rifampicin decreases sunitinib concentrations: in healthy adult volunteers, coadministration with a single sunitinib dose reduced combined sunitinib-plus-primary-metabolite maximum concentration (Cmax) by 23% and exposure (AUC) by 46%.

Sources for this answer

Sunitinib 12.5mg Hard CapsulesTeva UK Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 3Document updated 20 June 2024

Sources checked 8 November 2026

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