Answer
Rifampicin decreases pioglitazone hydrochloride exposure (AUC) by 54% when co-administered; the pioglitazone dose may need to be increased, and close monitoring of glycaemic control should be considered.
Sources for this answer
- Pioglitazone 45 mg TabletsSandoz Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 6Document updated
Sources checked