Answer
Rifampicin decreases mean edoxaban exposure (AUC) and shortens its half-life, potentially reducing its pharmacodynamic effects, so edoxaban should be used cautiously with rifampicin.
Sources for this answer
- Lixiana Film-Coated TabletsDaiichi Sankyo UK Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 10Document updated
Sources checked