Answer
Rifampicin induces buspirone hydrochloride metabolism via CYP3A4; in healthy volunteers, rifampicin (600 mg daily for five days) with a single 30 mg buspirone dose reduced Cmax by 84%, AUC by 90% and its pharmacodynamic effect.
Sources for this answer
- Buspirone Hydrochloride 5 mg TabletsViatris (formerly Mylan or Upjohn) · emc · SmPC §4.5 Interaction with other medicinal products · Version 4Document updated
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