Answer
Rifampicin reduces saxagliptin hydrochloride peak blood concentration (Cmax) by 53% and overall exposure (AUC) by 76%, without affecting exposure to its active metabolite or plasma DPP4 activity inhibition over a dose interval.
Sources for this answer
- Onglyza 5mg film-coated tabletsAstraZeneca UK Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 26Document updated
Sources checked