Saxagliptin · Medicine question

How does rifampicin affect blood levels of Saxagliptin?

iatroX medicinesPublished 8 November 2026

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Rifampicin reduced Saxagliptin peak blood concentration (Cmax) by 53% and overall exposure (AUC) by 76%, without affecting exposure to its active metabolite or plasma DPP4 inhibition over a dosing interval.

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Saxagliptin 2.5 mg Film-coated TabletsCelix Pharma Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 1Document updated 14 May 2026

Sources checked 8 November 2026

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