Answer
Radium-223 dichloride (Xofigo) mimics calcium and targets bone metastases by forming complexes with hydroxyapatite; its alpha particles have high linear energy transfer (80 keV/µm), causing frequent double-strand DNA breaks in adjacent tumour cells and a potent cytotoxic effect.
Sources for this answer
- Xofigo 1100 kBq/mL solution for injectionBayer plc · emc · SmPC §5.1 Pharmacodynamic properties · Version 11Document updated
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