Answer
Probenecid interferes with renal tubular transfer of cefotaxime sodium, approximately doubling exposure and halving renal clearance at therapeutic doses; no dosage adjustment is needed with normal renal function, but adjustment may be needed with renal impairment.
Sources for this answer
- Cefotaxime 500mg, 1g Powder for solution for injection or infusion PL 29831/0030Wockhardt UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 10Document updated
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