pimecrolimus · Medicine question

How does pimecrolimus reduce inflammation?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Pimecrolimus binds to macrophilin-12 and inhibits the calcium-dependent phosphatase calcineurin, blocking the synthesis of inflammatory cytokines in T cells.

Sources for this answer

Elidel 10mg/g creamViatris (formerly Mylan or Upjohn) · emc · SmPC §5.1 Pharmacodynamic properties · Version 9Document updated 5 March 2026

Sources checked 8 November 2026

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