Answer
Pemetrexed disrupts folate-dependent processes essential for cell replication by inhibiting thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase, as shown in vitro, thereby interfering with thymidine and purine nucleotide synthesis.
Sources for this answer
- Pemetrexed 25 mg/ml concentrate for solution for infusionGenus Pharmaceuticals · emc · SmPC §5.1 Pharmacodynamic properties · Version 2Document updated
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