Answer
Pemetrexed diarginine disrupts folate-dependent processes essential for cell replication by inhibiting thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase, as shown in vitro, thereby impairing thymidine and purine nucleotide synthesis.
Sources for this answer
- Pemetrexed 25mg/ml concentrate for solution for infusionAspire Pharma Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 4Document updated
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