How does pegcetacoplan reduce C3 deposits in the kidneys in C3 glomerulopathy and primary immune complex membranoproliferative glomerulonephritis?

In C3 glomerulopathy and primary immune complex membranoproliferative glomerulonephritis, pegcetacoplan binds C3 and C3b, inhibiting all three complement pathways (alternative, classical and lectin) and alternative-pathway C3 convertase activity, thereby reducing excessive C3 breakdown-product deposition in kidney glomeruli.