Answer
Pasireotide pamoate (Signifor) inhibits ACTH secretion by binding to and activating four of five human somatostatin receptor subtypes, especially hsst5, in corticotrophs of ACTH-producing adenomas; in vitro studies show high hsst5 expression in corticotroph tumour cells from patients with Cushing's disease.
Sources for this answer
- Signifor 10 mg powder and solvent for suspension for injectionRecordati Rare Diseases UK Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 12Document updated
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