oxaliplatin · Medicine question

How does oxaliplatin disrupt DNA synthesis to produce its antitumour effects?

Name: How does oxaliplatin disrupt DNA synthesis to produce its antitumour effects?
Published: 2026-11-08T14:26:46.613Z

iatroX medicinesPublished 8 November 2026

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Although its mechanism is not completely elucidated, aqua-derivatives formed by oxaliplatin biotransformation interact with DNA to form inter- and intra-strand cross-links, disrupting DNA synthesis and producing cytotoxic and antitumour effects.

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Oxaliplatin 5 mg/ml concentrate for solution for infusionRanbaxy (UK) Limited a Sun Pharmaceutical Company · emc · SmPC §5.1 Pharmacodynamic properties · Version 11Document updated 5 January 2026

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