Answer
In allergic asthma, omalizumab selectively binds human IgE, preventing its binding to high-affinity FcεRI receptors on mast cells and basophils and reducing free IgE available to trigger the allergic cascade.
Sources for this answer
- Xolair 150mg Solution for Injection in pre-filled syringeNovartis Pharmaceuticals UK Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 22Document updated
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