Answer
Olezarsen sodium selectively binds apolipoprotein C3 (apoC-III) messenger RNA, triggering its degradation through RNase H1-mediated cleavage, which reduces serum apoC-III protein and thereby lowers plasma triglycerides.
Sources for this answer
- Tryngolza 80 mg solution for injection in pre-filled penSwedish Orphan Biovitrum Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 1Document updated
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