Nirsevimab · Medicine question

How does nirsevimab block RSV from entering cells?

iatroX medicinesPublished 8 November 2026

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Nirsevimab binds to the prefusion RSV F protein and inhibits the essential membrane-fusion step in viral entry, neutralising RSV and blocking cell-to-cell fusion.

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Beyfortus 100 mg solution for injection in pre filled syringeSANOFI · emc · SmPC §5.1 Pharmacodynamic properties · Version 3Document updated 21 May 2026

Sources checked 8 November 2026

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Does nirsevimab interfere with RSV RT-PCR tests or rapid antigen tests targeting sites I, II or IV of the RSV F protein?Have serious hypersensitivity reactions been reported after nirsevimab (Beyfortus) administration?How is nirsevimab (Beyfortus) administered, and which injection site is preferred?How much polysorbate 80 does a 100 mg pre-filled syringe of nirsevimab (Beyfortus) contain?What was the most frequently reported adverse reaction to nirsevimab in clinical trials?

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