How does niraparib tosylate monohydrate cause DNA damage and cell death in laboratory studies?

Niraparib tosylate monohydrate inhibits PARP-1 and PARP-2, enzymes involved in DNA repair, and laboratory studies suggest its cytotoxicity may involve inhibition of PARP enzymatic activity and increased PARP–DNA complex formation, resulting in DNA damage, apoptosis and cell death.