Montelukast · Medicine question

How does montelukast work in asthma?

iatroX medicinesPublished 8 November 2026

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Answer

Montelukast selectively blocks cysteinyl leukotriene CysLT1 receptors, inhibiting leukotriene-induced airway narrowing and reducing eosinophilic inflammation.

Sources for this answer

Singulair Paediatric 5 mg Chewable TabletsOrganon Pharma (UK) Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 19Document updated 6 October 2022

Sources checked 8 November 2026

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Does taking montelukast remove the need for people with aspirin-sensitive asthma to avoid aspirin and other NSAIDs?Is montelukast indicated to prevent asthma in which exercise-induced bronchoconstriction is the predominant component?Can Singulair (montelukast) affect driving or the use of machines?How does gemfibrozil affect exposure to montelukast?How much lactose monohydrate does each Singulair 10 mg montelukast film-coated tablet contain?Should Singulair Paediatric 5 mg montelukast chewable tablets be chewed before swallowing?

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