How does mild or moderate renal impairment affect gemtuzumab ozogamicin clearance according to population pharmacokinetic analysis?

Population pharmacokinetic analysis in 406 patients found gemtuzumab ozogamicin clearance similar with mild (creatinine clearance 60–89 mL/min) or moderate (30–59 mL/min) renal impairment versus normal renal function (≥90 mL/min); no formal renal impairment studies were conducted, and severe impairment has not been studied.