Answer
Mesna is converted to dimesna, transported to the kidneys and reduced in the renal tubular epithelium to a free thiol compound that reacts chemically with toxic oxazaphosphorine metabolites in urine.
Sources for this answer
- Mesna Tablets 600 mgBaxter Healthcare Ltd · emc · SmPC §5.2 Pharmacokinetic properties · Version 1Document updated
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