melphalan · Medicine question

How does melphalan prevent cells from replicating?

iatroX medicinesPublished 8 November 2026

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Melphalan is a bifunctional alkylating agent that binds covalently to the 7-nitrogen of guanine in DNA, cross-linking two DNA strands and thereby preventing cell replication.

Sources for this answer

Melphalan 2 mg TabletsAspen · emc · SmPC §5.1 Pharmacodynamic properties · Version 17Document updated 20 March 2025

Sources checked 8 November 2026

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