How does linaclotide act on guanylate cyclase-C receptors in the intestine?

Linaclotide and its active metabolite bind to and activate guanylate cyclase-C receptors on the luminal surface of intestinal epithelial cells, increasing intracellular and extracellular cGMP, with intracellular cGMP promoting chloride and bicarbonate secretion through CFTR, increasing intestinal fluid and accelerating transit.