Answer
Lidocaine in Covonia slows depolarisation by blocking the large transient increase in cell-membrane permeability to sodium ions following initial depolarisation, thereby impairing nerve impulse generation and conduction; it also reduces resting axon permeability to potassium and sodium ions.
Sources for this answer
- Covonia Sore Throat 0.2%/0.05%w/v Oromucosal Spray Menthol FlavourThornton & Ross Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 9Document updated
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