letrozole · Medicine question

How does letrozole reduce oestrogen production?

iatroX medicinesPublished 8 November 2026

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Answer

Letrozole reduces oestrogen production by competitively binding to the haem of aromatase cytochrome P450, inhibiting the aromatase enzyme responsible for oestrogen biosynthesis.

Sources for this answer

Femara 2.5 mg TabletsNovartis Pharmaceuticals UK Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 35Document updated 2 September 2025

Sources checked 8 November 2026

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