Answer
In ledipasvir + sofosbuvir, ledipasvir targets HCV NS5A, essential for viral RNA replication and virion assembly, while sofosbuvir is converted intracellularly into an active uridine analogue triphosphate that is incorporated into viral RNA by HCV NS5B RNA polymerase and terminates the RNA chain.
Sources for this answer
- Ledipasvir/Sofosbuvir Gilead 90 mg/400 mg film-coated tabletsGilead Sciences Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 6Document updated
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