Answer
Ketoconazole increases exposure to Vanflyta’s quizartinib, potentially increasing toxicity; ketoconazole 200 mg twice daily for 28 days with a single Vanflyta dose increased quizartinib Cmax and AUCinf by 1.17-fold and 1.94-fold, respectively.
Sources for this answer
- Vanflyta 17.7 mg film-coated tabletDaiichi Sankyo UK Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 4Document updated
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