Answer
Ketoconazole, a strong CYP3A4 inhibitor, increases tamsulosin AUC 2.8-fold and peak concentration 2.2-fold; the combination requires caution and should not be used in patients with the poor-metaboliser CYP2D6 phenotype.
Sources for this answer
- Flomaxtra XL, 400 micrograms, film-coated prolonged release tabletAstellas Pharma Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 15Document updated
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