Answer
Ketoconazole, a potent CYP3A4 inhibitor, increases exposure to sublingual sufentanil citrate, raising peak plasma concentrations by 19% and overall exposure (AUC) by 77%, while prolonging the time to peak concentration by 41%.
Sources for this answer
- Dzuveo 30mcg Sublingual tabletAguettant Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 4Document updated
Sources checked