Answer
In 24 healthy subjects under fasting conditions, five daily 400 mg ketoconazole doses increased the Cmax of a single 100 mg bosutinib dose 5.2-fold and its plasma AUC 8.6-fold compared with bosutinib alone.
Sources for this answer
- Bosutinib 100 mg film-coated tabletsDr. Reddy's Laboratories (UK) Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 2Document updated
Sources checked