Answer
Itraconazole increased ripretinib peak concentration (Cmax) by 36% and total exposure (AUC) by 99%, while active metabolite DP-5439 Cmax was unchanged and AUC increased by 99%; this combination requires caution and patient monitoring.
Sources for this answer
- QINLOCK 50 mg tabletsDeciphera · emc · SmPC §4.5 Interaction with other medicinal products · Version 2Document updated
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