Answer
Itraconazole, a strong CYP3A4 inhibitor, increased omaveloxolone exposure (AUC) approximately fourfold and maximum plasma concentration approximately threefold in a clinical study; if concurrent use is unavoidable, Skyclarys dose reduction with monitoring should be considered.
Sources for this answer
- Skyclarys 50mg Hard CapsulesBiogen Idec Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 3Document updated
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