Answer
Intravenous fentanyl decreases etomidate’s total plasma clearance and volume of distribution by a factor of 2 to 3 without changing its half-life, so the etomidate dose may need to be reduced.
Sources for this answer
- HypnomidatePiramal Critical Care Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 3Document updated
Sources checked