Answer
In LHON, idebenone can transfer electrons directly to complex III of the mitochondrial electron transport chain, bypassing complex I, which is affected by all three primary LHON-causing mitochondrial DNA mutations, and restoring cellular ATP generation.
Sources for this answer
- Raxone 150 mg film-coated tabletsChiesi Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 7Document updated
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