Answer
Glasdegib maleate binds to and inhibits Smoothened (SMO), inhibiting Hedgehog signalling and thereby reducing GLI1 levels and the leukaemic initiating potential of acute myeloid leukaemia cells.
Sources for this answer
- Daurismo 100mg Film Coated TabletsPfizer Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 6Document updated
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