Answer
Albutrepenonacog alfa is fused with recombinant albumin, a natural, inert plasma carrier protein with an approximately 20-day half-life, prolonging its half-life and systemic exposure; the fusion remains intact in circulation until factor IX activation cleaves off albumin.
Sources for this answer
- Idelvion 250, 500, 1000, 2000 and 3500 IU powder and solvent for solution for injectionCSL Behring UK Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 13Document updated
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