Answer
Fomepizole competitively inhibits alcohol dehydrogenase, the enzyme catalysing the first stage of ethylene glycol metabolism in the liver, thereby blocking toxic metabolite formation and allowing ethylene glycol to be eliminated unchanged in urine.
Sources for this answer
- Fomepizole Waymade 1 g/ml concentrate for solution for infusionSovereign Medical · emc · SmPC §5.1 Pharmacodynamic properties · Version 1Document updated
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