Answer
Fluvoxamine inhibits CYP1A2, considerably reducing lidocaine hydrochloride elimination and increasing toxicity risk; concurrent CYP3A4 inhibition, such as with erythromycin, can further increase lidocaine concentrations, so dose adjustment may be needed.
Sources for this answer
- Lidocaine Hydrochloride Injection BP 1% w/vhameln pharma ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 5Document updated
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