Answer
Fluconazole increases valdecoxib exposure, raising AUC by 62% and Cmax by 19%, so the parecoxib dose should be reduced in patients receiving fluconazole.
Sources for this answer
- Parecoxib Seacross 40 mg powder for solution for injectionSeacross Pharmaceuticals Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 1Document updated
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