Answer
When taken with Madopar, ferrous sulfate decreases levodopa’s maximum plasma concentration and exposure (AUC) by 30–50%, with these changes appearing clinically significant in some but not all patients.
Sources for this answer
- Madopar CR 100 mg/25 mg Prolonged Release Hard CapsulesRoche Products Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 18Document updated
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