Answer
Entecavir, a guanosine nucleoside analogue, is phosphorylated to its active triphosphate form, which competes with deoxyguanosine triphosphate to inhibit HBV polymerase priming, reverse transcription of negative-strand DNA from pregenomic messenger RNA, and synthesis of positive-strand HBV DNA.
Sources for this answer
- Baraclude 0.05 mg/ml oral solutionBristol Myers Squibb Pharmaceuticals limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 6Document updated
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