Answer
Emtricitabine/tenofovir disoproxil inhibits HIV-1 replication after tenofovir disoproxil is converted to tenofovir and cellular enzymes phosphorylate emtricitabine and tenofovir to emtricitabine triphosphate and tenofovir diphosphate, which competitively inhibit HIV-1 reverse transcriptase, resulting in DNA chain termination.
Sources for this answer
- Emtricitabine/Tenofovir disoproxil Lupin 200 mg/245 mg Film-coated TabletsLupin Healthcare (UK) Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 6Document updated
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