emtricitabine · Medicine question

How does emtricitabine inhibit HIV-1 replication?

iatroX medicinesPublished 8 November 2026

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Cellular enzymes phosphorylate emtricitabine to emtricitabine 5'-triphosphate, which competitively inhibits HIV-1 reverse transcriptase, resulting in DNA chain termination.

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Emtriva 200 mg hard capsulesGilead Sciences Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 31Document updated 20 June 2023

Sources checked 8 November 2026

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