disulfiram · Medicine question

How does disulfiram inhibit alcohol metabolism?

iatroX medicinesPublished 8 November 2026

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Disulfiram primarily irreversibly inactivates liver acetaldehyde dehydrogenase (ALDH), blocking ethanol metabolism and increasing intracellular acetaldehyde concentrations.

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Disulfiram 200 mg tabletsBrown & Burk UK Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 4Document updated 17 October 2025

Sources checked 8 November 2026

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