Answer
Decitabine selectively inhibits DNA methyltransferases at low doses, causing gene promoter hypomethylation that can reactivate tumour suppressor genes.
Sources for this answer
- Dacogen 50 mg powder for concentrate for solution for infusion.(Great Britain)Janssen-Cilag Ltd (a Johnson & Johnson Company) · emc · SmPC §5.1 Pharmacodynamic properties · Version 16Document updated
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