Answer
Cyclosporin A coadministered as a single chemosensitizer significantly increased idarubicin hydrochloride exposure (AUC) 1.78-fold and its metabolite idarubicinol exposure 2.46-fold in patients with acute leukaemia; the clinical significance is unknown, and dosage adjustment may be necessary in some patients.
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- Zavedos 5mg CapsulesPfizer Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 16Document updated
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